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  "Package": "htrSPRanalysis",
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  "Title": "Analysis of Surface Plasmon Resonance Data",
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  "Authors@R": "c(person(\"Janice McCarthy\", \"Developer\", role = c(\"aut\", \"cre\",\"cph\"),email = \"janice.mccarthy@duke.edu\"),person(\"Kan Li\", \"Dev\", role = \"aut\"),person(\"S. Moses Dennison\", role = \"aut\"),person(\"Georgia D. Tomaras\", role = \"aut\"))",
  "Description": "Analysis of Surface Plasmon Resonance (SPR) and Biolayer\nInterferometry data, with automations for high-throughput SPR.\nThis version of the package fits the 1: 1 binding model, with\nand without bulkshift. It offers optional local or global Rmax\nfitting. The user must provide a sample sheet and a Carterra\noutput file in Carterra's current format. There is a utility\nfunction to convert from Carterra's old output format. The user\nmay run a custom pipeline or use the provided 'Runscript',\nwhich will produce a pdf file containing fitted Rmax, ka, kd\nand standard errors, a plot of the sensorgram and fits, and a\nplot of residuals. The script will also produce a .csv file\nwith all of the relevant parameters for each spot on the SPR\nchip.",
  "License": "GPL (>= 3)",
  "Encoding": "UTF-8",
  "VignetteBuilder": "knitr",
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  "Packaged": {
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    "User": "root"
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  "Author": "Janice McCarthy Developer [aut, cre, cph], Kan Li Dev [aut], S.\nMoses Dennison [aut], Georgia D. Tomaras [aut]",
  "Maintainer": "Janice McCarthy Developer <janice.mccarthy@duke.edu>",
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  "Repository": "https://janice-mccarthy.r-universe.dev",
  "Date/Publication": "2026-05-21 07:30:07 UTC",
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    "create_csv",
    "create_pdf",
    "get_fits",
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    "get_plots_before_baseline",
    "get_rc_plots",
    "process_input"
  ],
  "_help": [
    {
      "page": "create_csv",
      "title": "Create csv file with all fit parameters.",
      "topics": [
        "create_csv"
      ]
    },
    {
      "page": "create_pdf",
      "title": "Create pdf file with sensorgrams with fitted curves, residuals, table of fit parameters, and response curves.",
      "topics": [
        "create_pdf"
      ]
    },
    {
      "page": "get_fits",
      "title": "Get fits of all selected sensorgrams as indicated in the sample information.",
      "topics": [
        "get_fits"
      ]
    },
    {
      "page": "get_fitted_plots",
      "title": "Plot fitted sensorgras and raw data.",
      "topics": [
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      ]
    },
    {
      "page": "get_plots_before_baseline",
      "title": "Plot all raw data that has been selected to be processed (via the 'Incl.' column in the sample information). No adjustments are made to the data.",
      "topics": [
        "get_plots_before_baseline"
      ]
    },
    {
      "page": "get_rc_plots",
      "title": "Plot response curve. Average RU versus log10 of concentration. Color coded for concentrations selected for fitting.",
      "topics": [
        "get_rc_plots"
      ]
    },
    {
      "page": "process_input",
      "title": "Process user input files and obtain options for fitting.",
      "topics": [
        "process_input"
      ]
    }
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      "filename": "htrSPRanalysis-vignette.html",
      "title": "Introduction to htrSPRanalysis",
      "engine": "knitr::knitr",
      "headings": [
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        "Sample information column definitions",
        "Reading and processing input files, obtaining user supplied options",
        "Output",
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        "Fit the data to the 1:1 Languir model",
        "Plot the sensorgrams with fitted curves",
        "Create the response curve plots",
        "Create a pdf with fitted sensorgrams, curve parameters, standard errors, residual plot and response curve.",
        "Create a .csv file with all model parameters and standard errors.",
        "Bulk shift example",
        "Pipeline"
      ],
      "created": "2024-08-27 02:49:41",
      "modified": "2026-05-05 11:43:32",
      "commits": 2
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